Week 16 Injuries: Two QBs out, meaning two huge blows to two NFL teams

Oakland Raiders QB Derek Carr broke his right fibula in the fourth quarter as his cleat got stuck in the ground while Colts OLB Trent Cole sacked him.

He will have surgery Sunday and is out indefinitely. Carr, an MVP candidate, immediately grabbed his leg and stayed on the turf.

It was only the second time all game the Colts pressured Carr behind one of the NFL's best offensive lines.

Trainers helped him off the field, and Carr couldn't put weight on his right leg. They examined Carr on the sideline before carting him to the locker room.

Matt McGloin replaced the QB in the lineup.

Mariota has fractured fibula: Tennessee Titans QB Marcus Mariota had to be carted off the field in the third quarter after injuring his right leg.

Coach Mike Mularkey said after the game that Mariota has a fractured fibula, adding, "Obviously, he is out."

Matt Cassel replaced the second-year QB in the lineup as the Titans fell to the Jaguars.

Seahawks lose Lockett: Seattle Seahawks WR Tyler Lockett made an incredible near-TD catch late in the second quarter, but he suffered a serious right leg injury on the play.

A source told ESPN that Lockett's leg is broken and that he'll have surgery Sunday morning.

His ankle got pinned under Cardinals CB Brandon Williams as he dove for the catch.

The second-year WR was in visible pain as trainers put an air cast on his leg and carted him off the field.

Other Key Injuries: Carlos Hyde (RB, SF), Cameron Brate (TE, TB), Thomas Rawls (RB, SEA), Robert Griffin III (QB, CLE)